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Repeatability of ultrashort echo time‐based two‐component T2* measurements on cartilages in human knee at 3 T

Identifieur interne : 005D32 ( Main/Exploration ); précédent : 005D31; suivant : 005D33

Repeatability of ultrashort echo time‐based two‐component T2* measurements on cartilages in human knee at 3 T

Auteurs : Yongxian Qian [États-Unis] ; Ashley A. Williams [États-Unis] ; Constance R. Chu [États-Unis] ; Fernando E. Boada [États-Unis]

Source :

RBID : ISTEX:127856AA6CEE5C6FECF7B227A857D6365CE5EF14

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English descriptors

Abstract

Repeatability of in vivo measurement of multicomponent T2* relaxation in articular cartialges in human knee is important to clinical use. This study evaluated the repeatability of two‐component T2* relaxation on seven healthy human subjects. The left knee was scanned once a day in three consecutive days, on a clinical 3T MRI scanner with eight‐channel knee coil and ultrashort echo time pulse sequence at 11 echo times = 0.6–40 ms. The intrasubject and intersubject repeatability was evaluated via coefficient of variation (CV = standard deviation/mean) in four typical cartilage regions: patellar, anterior articular, femoral, and tibial regions. It was found that the intrasubject repeatability was good, with CV < 10% for the short‐ and long‐T2* relaxation time in the layered regions in the four cartilages (with one exception) and CV < 13% for the component intensity fraction (with two exceptions). The intersubject repeatability was also good, with CV ∼8% (range 1–15%) for the short‐ and long‐T2* relaxation time and CV ∼10% (range 2–20%) for the component intensity fraction. The long‐T2* component showed significantly better repeatability (CV ∼8%) than the short‐T2* component (CV∼12%) (P < 0.005). These CV values suggest that in vivo measurement of two‐component T2* relaxation in the knee cartilages is repeatable on clinical scanner at 3 T, with a signal‐to‐noise ratio of 90. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.

Url:
DOI: 10.1002/mrm.24392


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<term>Articular cartilages</term>
<term>Background noise</term>
<term>Better repeatability</term>
<term>Biexponential</term>
<term>Bydder</term>
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<term>Color figure</term>
<term>Component intensity</term>
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<term>Consecutive days</term>
<term>Constant term</term>
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<term>Different subjects</term>
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<term>Femoral cartilage</term>
<term>Fitting process</term>
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<term>Intersubject repeatability</term>
<term>Intrasubject</term>
<term>Intrasubject repeatability</term>
<term>Knee cartilage</term>
<term>Knee cartilages</term>
<term>Knee coil</term>
<term>Large mismatches</term>
<term>Lateral side</term>
<term>Logarithmic scale</term>
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<term>Previous studies</term>
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<term>Radiofrequency excitation</term>
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<term>Relaxation properties</term>
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<term>Relaxation times</term>
<term>Repeatability</term>
<term>Reson</term>
<term>Roi</term>
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<term>Wiley periodicals</term>
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<term>Anterior articular</term>
<term>Arbitrary unit</term>
<term>Articular</term>
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<term>Background noise</term>
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<term>Biexponential</term>
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<term>Collagen fiber orientation</term>
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<term>Color figure</term>
<term>Component intensity</term>
<term>Component intensity fraction</term>
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<term>Consecutive days</term>
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<term>Fitting process</term>
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<term>Grant sponsor</term>
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<term>Human subjects</term>
<term>Image intensity</term>
<term>Imaging</term>
<term>Imaging marker</term>
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<term>Individual subjects</term>
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<div type="abstract" xml:lang="en">Repeatability of in vivo measurement of multicomponent T2* relaxation in articular cartialges in human knee is important to clinical use. This study evaluated the repeatability of two‐component T2* relaxation on seven healthy human subjects. The left knee was scanned once a day in three consecutive days, on a clinical 3T MRI scanner with eight‐channel knee coil and ultrashort echo time pulse sequence at 11 echo times = 0.6–40 ms. The intrasubject and intersubject repeatability was evaluated via coefficient of variation (CV = standard deviation/mean) in four typical cartilage regions: patellar, anterior articular, femoral, and tibial regions. It was found that the intrasubject repeatability was good, with CV < 10% for the short‐ and long‐T2* relaxation time in the layered regions in the four cartilages (with one exception) and CV < 13% for the component intensity fraction (with two exceptions). The intersubject repeatability was also good, with CV ∼8% (range 1–15%) for the short‐ and long‐T2* relaxation time and CV ∼10% (range 2–20%) for the component intensity fraction. The long‐T2* component showed significantly better repeatability (CV ∼8%) than the short‐T2* component (CV∼12%) (P < 0.005). These CV values suggest that in vivo measurement of two‐component T2* relaxation in the knee cartilages is repeatable on clinical scanner at 3 T, with a signal‐to‐noise ratio of 90. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.</div>
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